The systemic nature and the resistance capability of disseminated tumor cells to existing therapeutic agents, could explain why 90% of cancer mortalities are attributable to metastases.
Based on these observations, our laboratory is focused on studying the biological program that enables resident Cancer Stem Cells (CSCs) to acquire a number of traits required to accomplish the fundamental steps in initiating the metastatic cascade.
For most cancers, the target cell responsible for transforming mutations is unknown. Considerable evidence states that certain types of leukaemia arise from mutations which accumulate in hematopoietic SCs. This observation mostly reflects the need to better understand the oncogenic events which occur in tissue-resident stem cells in order to explain the transition from non-malignant hyper-proliferative lesion to well established cancers and translate the identified mutations into new therapies. We study the initial events leading to thyroid tumor growth and the tumour-related molecular alterations, which characterize the tumor’s behavior.
CSCs have shown to possess an unlimited proliferative potential. These cells are responsible for the development of the tumor and represent the only cell population able to sustain tumor growth. Metastases spawned by the primary colon cancer is activated following the completion of molecular events attributable to CSCs. The mechanisms underlying colon cancer metastatic events, are far from being completely comprehended and it is still unclear which cell subset is able to migrate, survive and grow at the metastatic site. The inefficacy of conventional therapies in association with the CSC population, might explain cancer chemo-resistance and the high frequency of relapse and progression, shown by the majority of colon cancers. The CSC model suggests that it may be necessary to alter the current paradigm used in drug development. The eradication of cancers may require the targeting and elimination of CSCs, in order to improve therapeutic outcomes for patients that are affected with even the most advanced cancers and to prevent recurrence and metastases.Focus ultima modifica: 2015-10-12T11:23:11+00:00 da